Ku-55933
货号：
16336-1mg 基本售价：
630.0 元 规格：
1 mg
产品信息
概述| 货号 | 16336-1mg |
| 描述 | Ku-55933 is a potent ATP-competitive inhibitor of the ataxia-telangiectasia mutated (ATM) kinase (IC50 = 13 nM; Ki = 2.2 nM).1 Inhibition of ATM by Ku-55933 blocks radiation-induced phosphorylation of downstream cellular targets and sensitizes cells to the cytotoxic effects of both ionizing radiation and chemotherapeutic agents.1 Ku-55933 induces senescent breast, lung, and colon carcinoma cells to undergo cell death.2 It also inhibits HIV-1 replication in C8166 human T-lymophocyte cells with an IC50 value of 2.4 µM.3 |
| 别名 | ATM Kinase Inhibitor; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hickson, I.,Zhao, Y.,Richardson, C.J., et al. Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM. Cancer Research 64(24), 9152-9159 (2004).
2.Crescenzi, E.,Palumbo, G.,de Boer, J., et al. Ataxia telangiectasia mutated and p21CIP1 modulate cell survival of drug-induced senescent tumor cells: Implications for chemotherapy. Clinical Cancer Research 14(6), 1877-1887 (2008).
3.Lau, A.,Swinbank, K.M.,Ahmed, P.S., et al. Suppression of HIV-1 infection by a small molecule inhibitor of the ATM kinase. Nat.Cell.Biol. 7(5), 493-500 (2005).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 395.5 |
| 分子式 | C21H17NO3S2 |
| CAS号 | 587871-26-9 |
| 稳定性 | ≥ 2 years |
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