| 货号 | 16276-5mg |
| 描述 | PR-619 is a general inhibitor of deubiquitylating enzymes (DUBs), significantly reducing the activity of a panel of DUBs with EC50 values ranging from 5-20 µM.1 It is cell-permeable and reversible in its action.1 It is selective for DUBs over other proteases.1 PR-619 induces the accumulation of polyubiquitinated proteins in cells, including those not involved in the ubiquitin-proteasome system.2 It is used to study the role of DUBs in diverse pathways, including protein turnover and neurodegeneration.3,4,5 |
| 别名 | 2,6-Diamino-3,5-dithiocyanopyridine;DUB Inhibitor V; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Altun, M.,Kramer, H.B.,Willems, L.I., et al. Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. Chemistry & Biology 18(11), 1401-1412 (2011). 2.Udeshi, N.D.,Mani, D.R.,Eisenhaure, T., et al. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. Mol.Cell.Proteomics 11(15), 148-159 (2012). 3.Balut, C.M.,Loch, C.M. and Devor, D.C. Role of ubiquitylation and USP8-dependent deubiquitylation in the endocytosis and lysosomal targeting of plasma membrane KCa3.1. The FASEB Journal 25(11), 3938-3948 (2011). 4.Seiberlich, V.,Goldbaum, O.,Zhukareva, V., et al. The small molecule inhibitor PR-619 of deubiquitinating enzymes affects the microtubule network and causes protein aggregate formation in neural cells: Implications for neurodegenerative diseases. Biochimica et Biophysica Acta 1823(11), 2057-2068 (2012). 5.Bertuccio, C.A.,Lee, S.L.,Wu, G., et al. Anterograde trafficking of KCa3.1 in polarized epithelia is Rab1- and Rab8-dependent and recycling endosome-independent. PLoS One 9(3), 1-16 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 223.3 |
| 分子式 | C7H5N5S2 |
| CAS号 | 2645-32-1 |
| 稳定性 | ≥ 2 years |
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