GNE-0877
货号：
16251-500ug 基本售价：
630.0 元 规格：
500 ug
产品信息
概述| 货号 | 16251-500ug |
| 描述 | Leucine-rich repeat kinase 2 (LRRK2) is an enzyme that interacts with parkin, a ligase that is part of the ubiquitin-proteasome system that mediates the targeting of proteins for degradation. Loss of function of the parkin protein leads to dopaminergic cell death. The development of Parkinsons disease has been strongly associated with mutations in the LRRK2 gene that lead to increased kinase activity. GNE 0877 is a selective, brain-penetrable LRRK2 inhibitor (Ki = 0.7 nM).1 It inhibits LRRK2 Ser1292 autophosphorylation in BAC transgenic mice expressing human LRRK2 protein with the G2019S Parkinson’s disease mutation with an IC50 value of 3 nM in vivo.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Estrada, A.A.,Chan, B.K.,Baker-Glenn, C., et al. Discovery of highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors. Journal of Medicinal Chemistry 57(3), 921-936 (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 339.3 |
| 分子式 | C14H16F3N7 |
| CAS号 | 1374828-69-9 |
| 稳定性 | ≥ 2 years |
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