AGK7
货号：
16152-1mg 基本售价：
630.0 元 规格：
1 mg
产品信息
概述| 货号 | 16152-1mg |
| 描述 | AGK2 (Item No. 13145) is a cell-permeable, selective inhibitor of SIRT2 (IC50 = 3.5 μM) that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels.1,2 AGK7 is an inactive control to be used in experiments with AGK2. It differs from AGK2, structurally, only in the position of nitrogen in the quinoline group.1 AGK7 has IC50 values greater than 50 µM on SIRT1 and SIRT2 and greater than 5 µM on SIRT3.1 |
| 别名 | SIRT2 Inhibitor (Inactive Control); |
性能| 供应商 | Cayman |
| 应用文献 |
1.Outeiro, T.F.,Kontopoulos, E.,Altmann, S.M., et al. Sirtuin 2 inhibitors rescue α-synuclein-mediated toxicity in models of Parkinson’s Disease. Science 317, 516-519 (2007).
2.Cole, P.A. Chemical probes for histone-modifying enzymes. Nature Chemical Biology 4(10), 590-597 (2008).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 434.3 |
| 分子式 | C23H13Cl2N3O2 |
| CAS号 | 304896-21-7 |
| 稳定性 | ≥ 2 years |
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