1-(1-Naphthyl) piperazine (hydrochloride)
货号：
16150-25mg 基本售价：
630.0 元 规格：
25 mg
产品信息
概述| 货号 | 16150-25mg |
| 描述 | 1-(1-Naphthyl) piperazine (1-NP) is a ligand for serotonin (5-hydroxytryptamine, 5-HT) receptors. It acts as an antagonist for 5-HT at 5-HT1 and 5-HT2 in rat cortical membranes with IC50 values of 6 and 1 nM, respectively.1 1-NP also blocks contraction in the rat fundus induced by either 5-HT or tryptamine (IC50 = 1 nM for both agonists).1 1-NP mimics the 5-HT1 agonist 1-(m-trifluoromethylphenyl)piperazine (TFMPP, Item No. 11205) in decreasing 5-HT receptor turnover and increasing serum corticosterone, suggesting that, in the absence of 5-HT, 1-NP may act as an agonist of the 5-HT1receptor.2 However, in squirrel monkeys, 1-NP acts as a non-selective 5-HT receptor antagonist in altering operant behavior.2 1-NP also binds to the human 5-HT6 receptor with an affinity comparable to that of 5-HT(Kis = 120 and 100 nM, respectively).3 |
| 别名 | 1-NP; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Cohen, M.L. and Wittenauer, L.A. Relationship between serotonin and tryptamine receptors in the rat stomach fundus. Journal of Pharmacology and Experimental Therapeutics 233(1), 75-79 (1985).
2.McKearney, J.W. Serotonin-antagonist effects of 1-(1-naphthyl)piperazine on operant behavior of squirrel monkeys. Neuropharmacology 28(8), 817-821 (1989).
3.Lee, M.,Rangisetty, J.B.,Pullagurla, M.R., et al. 1-(1-Naphthyl)piperazine as a novel template for 5-HT6 serotonin receptor ligands. Bioorganic & Medicinal Chemistry Letters 15(6), 1707-1711 (2005).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 248.7 |
| 分子式 | C14H16N2 • HCl |
| CAS号 | 104113-71-5 |
| 稳定性 | ≥ 2 years |
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