Levosimendan
货号：
16128-50mg 基本售价：
630.0 元 规格：
50 mg
产品信息
概述| 货号 | 16128-50mg |
| 描述 | Levosimendan is a calcium sensitizer that can cause increased cardiac contractility by binding troponin C (EC50 = 9 nM), promotes vasodilation by activating ATP-sensitive potassium channels on vascular smooth muscle cells (EC50 = 0.28 µM), and performs a cardioprotective function by prompting the opening of mitochondrial potassium channels in cardiomyocytes.1,2 It also has been reported to inhibit phosphodiesterases 3 and 4 in left ventricular cardiac tissue with IC50 values of 2.5 nM and 25 µM, respectively.3 |
| 别名 | OR 1259;Simdax®;(R)-Simendan; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Nieminen, M.S.,Fruhwald, S.,Heunks, L.M.A., et al. Levosimendan: Current data, clinical use and future development. Heart Lung Vessel 5(4), 227-245 (2013).
2.Papp, Z.,Csapó, K.,Pollesello, P., et al. Pharmacological mechanisms contributing to the clinical efficacy of levosimendan. Cardiovascular Drug Reviews 23(1), 71-98 (2005).
3.Szilágyi, S.,Pollesello, P.,Levijoki, J., et al. The effects of levosimendan and OR-1896 on isolated hearts, myocyte-sized preparations and phophodiesterase enzymes of the guinea pig. European Journal of Pharmacology 486, 67-74 (2004).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 280.3 |
| 分子式 | C14H12N6O |
| CAS号 | 141505-33-1 |
| 稳定性 | ≥ 2 years |
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