trans-3-Hydroxycotinine
货号：
16100-1mg 基本售价：
630.0 元 规格：
1 mg
产品信息
概述| 货号 | 16100-1mg |
| 描述 | trans-3’-Hydroxycotinine (3HC) is a product of CYP2A6 metabolism of the primary nicotine metabolite, cotinine (Item No. 15314).1,2 Cotinine has a longer metabolic half-life compared to 3HC (16 hours vs. 5 hours).1 The ratio of 3HC to cotinine, termed the nicotine metabolite ratio, correlates with nicotine clearance from the body and is used as a biomarker of CYP2A6 activity.1 This measure of nicotine metabolism has been used to study tobacco and secondhand smoke exposure as well as to develop pharmacological intervention strategies for smoking cessation.1,3 |
| 别名 | 3HC; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Zhu, A.Z.,Zhou, Q.,Cox, L.S., et al. Variation in trans-3-hydroxycotinine glucuronidation does not alter the nicotine metabolite ratio or nicotine intake. PLoS One 8(8), e70938 (2013).
2.von Weymarn, L.B.,Retzlaff, C. and Murphy, S.E. CYP2A6- and CYP2A13-catalyzed metabolism of the nicotine Δ5(1)iminium ion. Journal of Pharmacology and Experimental Therapeutics 343(2), 307-315 (2012).
3.Murphy, S.E.,Wickham, K.M.,Lindgren, B.R., et al. Cotinine and trans 3-hydroxycotinine in dried blood spots as biomarkers of tobacco exposure and nicotine metabolism. J.Expo.Sci.Environ.Epidermiol. 23(5), 513-518 (2013).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 192.2 |
| 分子式 | C10H12N2O2 |
| CAS号 | 34834-67-8 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
