OICR-9429
货号：
16095-1mg 基本售价：
630.0 元 规格：
1 mg
产品信息
概述| 货号 | 16095-1mg |
| 描述 | WD-repeat protein 5 (WDR5) is a scaffold protein commonly involved in the formation of nucleosome-modifying protein complexes with histones.1 For example, WDR5 is a component of a mixed-lineage leukemia (MLL) methyltransferase complex that targets histone 3.2 WDR5 can also be a component of histone acetyltransferase complexes and can directly bind methylated as well as unmodified histones.1,3 OICR-9429 is a chemical probe that inhibits the interaction of WDR5 with peptide regions of MLL and Histone 3, demonstrating >100-fold selectivity over other chromatin reader domains, methyltransferases, and other non-epigenetic targets. It selectively binds to WDR5 (Kd = 24-52 nM) and disrupts its interaction with MLL1 and RbBP5 in cells (IC50=<1 µM). See the Structural Genomics Consortium (SGC) website for more information. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Migliori, V.,Mapelli, M. and Guccione, E. On WD40 proteins: Propelling our knowledge of transcriptional control? Epigenetics 7(8), 815-822 (2012).
2.Guccione, E.,Bassi, C.,Casadio, F., et al. Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive. Nature 449, 933-937 (2007).
3.Guelman, S.,Kozuka, K.,Mao, Y., et al. The double-histone-acetyltransferase complex ATAC is essential for mammalian development. Molecular and Cellular Biology 29(5), 1176-1188 (2009).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 555.6 |
| 分子式 | C29H32F3N5O3 |
| CAS号 | 1801787-56-3 |
| 稳定性 | ≥ 2 years |
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