JNK Inhibitor VIII
货号：
15946-1mg 基本售价：
630.0 元 规格：
1 mg
产品信息
概述| 货号 | 15946-1mg |
| 描述 | c-Jun amino terminal kinases (JNKs) are MAP kinase family members that become highly activated after cells are exposed to stress conditions and are poorly activated by exposure to growth factors or mitogens.1 They have been implicated in neurodegeneration, rheumatoid arthritis, inflammation, cancer, and diabetes. JNK1 and JNK2 are widely expressed throughout the body whereas JNK3 is predominantly distributed in the brain. JNK Inhibitor VIII is an aminopyridine compound that inhibits JNK1, JNK2, and JNK3 with Ki values of 2, 4, and 52 nM, respectively.2 It has been reported to inhibit the phosphorylation of the JNK substrate c-Jun in HepG2 cells (EC50 = 920 nM) without affecting the expression of IL-6, IL-8, or COX-2.3 |
| 别名 | c-Jun N-terminal Kinase Inhibitor VIII; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Cowan, K.J. and Storey, K.B. Mitogen-activated protein kinases: New signaling pathways functioning in cellular responses to environmental stress. Journal of Experimental Biology 206, 1107-1115 (2003).
2.Szczepankiewicz, B.G.,Kosogof, C.,Nelson, L.T., et al. Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity. Journal of Medicinal Chemistry 49(12), 3563-3580 (2006).
3.Turpeinen, T.,Nieminen, R.,Moilanen, E., et al. Mitogen-activated protein kinase phosphatase-1 negatively regulates the expression of interleukin-6, interleukin-8, and cyclooxygenase-2 in A549 human lung epithelial cells. Journal of Pharmacology and Experimental Therapeutics 333(1), 310-318 (2010).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 356.4 |
| 分子式 | C18H20N4O4 |
| CAS号 | 894804-07-0 |
| 稳定性 | ≥ 2 years |
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