| 货号 | 15782-500ug |
| 描述 | Protein tyrosine phosphatase 1B (PTP1B) has critical roles in cell signaling relevant to diabetes, obesity, and cancer.1,2 PTP1B inhibitor is a cell-permeable allosteric inhibitor of PTP1B (IC50s = 4 and 8 µM for 403 and 298 residue PTP1B forms, respectively).3 It binds reversibly and non-competitively, altering the conformation of the catalytic pocket.3,4 PTP1B inhibitor selectively increases the phosphorylation of the insulin receptor, insulin receptor substrate 1, and Akt, mimicking the action of insulin.3 |
| 别名 | Protein Tyrosine Phosphatase 1B Inhibitor; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Zhang, S. and Zhang, Z.Y. PTP1B as a drug target: recent developments in PTP1B inhibitor discovery. Drug Discovery Today 12(9/10), 373-381 (2007). 2.Tonks, N.K. Protein tyrosine phosphatases - from housekeeping enzymes to master regulators of signal transduction. FEBS Journal 280(2), 346-378 (2013). 3.Wiesmann, C.,Barr, K.J.,Kung, J., et al. Allosteric inhibition of protein tyrosine phosphatase 1B. Nature Structural & Molecular Biology 11(8), 730-737 (2004). 4.Li, S.,Zhang, J.,Lu, S., et al. The mechanism of allosteric inhibition of protein tyrosine phosphatase 1B. PLoS One 9(5), e97668 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 741.5 |
| 分子式 | C26H19Br2N3O7S3 |
| CAS号 | 765317-72-4 |
| 稳定性 | ≥ 2 years |
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