Conoidin A
货号：
15605-25mg 基本售价：
630.0 元 规格：
25 mg
产品信息
概述| 货号 | 15605-25mg |
| 描述 | Peroxiredoxins are a widely conserved family of enzymes that function in antioxidant defense and act in redox signaling pathways. Increased expression of human peroxiredoxin is associated with cancer, cardiovascular dysfunction, and neurodegeneration. Conoidin A inactivates peroxiredoxins by covalently binding to the catalytic cysteine on the enzyme.1,2 It has been shown to inhibit peroxiredoxin II (IC50 = 23 µM) in the parasite T. gondii and peroxiredoxin I in the hookworm A. ceylanicum.1,3,2 At 5 µM, conoidin A can also inhibit the glucose oxidase-mediated hyperoxidation of mammalian peroxiredoxin I and II, but not peroxiredoxin III.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Haraldsen, J.D.,Liu, G.,Botting, C.H., et al. Identification of conoidin A as a covalent inhibitor of peroxiredoxin II. Organic & Biomolecular Chemistry 7, 3040-3048 (2009).
2.Nguyen, J.B.,Pool, C.D.,Wong, C.Y., et al. Peroxiredoxin-1 from the human hookworm Ancylostoma ceylanicum forms a stable oxidized decamer and is covalently inhibited by conoidin A. Chemistry & Biology 20(8), 991-1001 (2013).
3.Liu, G.,Botting, C.H.,Evans, K.M., et al. Optimisation of conoidin A, a peroxiredoxin inhibitor. ChemMedChem 5(1), 41-45 (2010).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 348 |
| 分子式 | C10H8Br2N2O2 |
| CAS号 | 18080-67-6 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
