SL 327
货号：
15598-1mg 基本售价：
630.0 元 规格：
1 mg
产品信息
概述| 货号 | 15598-1mg |
| 描述 | The dual specific threonine/tyrosine kinase MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates a diverse array of cellular processes. SL 327 is an inhibitor of MEK1 and MEK2 (IC50s = 0.18 and 0.22 μM), the kinases upstream of ERK1/2.1 It inhibits ERK1, MKK/p38, MKK4, JNK, and PKC at much higher concentrations (IC50s = >50, 21, >100, >100, >10 μM, respectively).1 Since SL 327 rapidly passes the blood-brain barrier, it has been used to dissect the effect of RAS/RAF/MEK/ERK signaling pathway inhibition on behavior, including long-term memory, spatial learning, and fear/operant conditioning.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Scherle, P.A.,Ma, W.g.,Lim, H., et al. Regulation of cyclooxygenase-2 induction in the mouse uterus during decidualization. The Journal of Biological Chemisty 275(47), 37086-37092 (2000).
2.Fasano, S. and Brambilla, R. Ras-ERK signaling in behavior: Old questions and new perspectives. Front.Behav.Neurosci. 5(79), (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% (mixture of cis/trans isomers) |
| 计算分子量 | 335.4 |
| 分子式 | C16H12F3N3S |
| CAS号 | 305350-87-2 |
| 稳定性 | ≥ 2 years |
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