PP3
货号：
15595-1mg 基本售价：
630.0 元 规格：
1 mg
产品信息
概述| 货号 | 15595-1mg |
| 描述 | The Src family of non-receptor tyrosine kinases regulate cell adhesion, growth, and differentiation through activation of multiple intracellular signaling pathways. Normally inactive, Src kinases are transiently activated during mitosis and constitutively activated by abnormal mutations. Several small molecule inhibitors of this signaling pathway have been developed as a therapeuptic strategy to abate abnormal Src kinase activity. PP3 is an inactive analog of the Src tyrosine kinase inhibitors PP1 (Item No. 14244) and PP2 (Item No. 13198). At concentrations as high as 10 μM, it does not prevent proliferation mediated by a stem cell factor/mast cell growth factor in hematopoietic and cancer cell lines.1,2 |
| 别名 | NSC 1401; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ungefroren, H.,Sebens, S.,Groth, S., et al. The Src family kinase inhibitors PP2 and PP1 block TGFβ-mediated cellular responses by direct and differential inhibition of type I and type II TGFβreceptors. Current Cancer Drug Targets 11(4), 524-535 (2011).
2.Tatton, L.,Morley, G.M.,Chopra, R., et al. The Src-selective kinase inhibitor PP1 also inhibits kit and Bcr-Abl tyrosine kinases. The Journal of Biological Chemisty 278(7), 4847-4853 (2003).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 211.2 |
| 分子式 | C11H9N5 |
| CAS号 | 5334-30-5 |
| 稳定性 | ≥ 2 years |
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