Fidaxomycin
货号：
15503-10mg 基本售价：
630.0 元 规格：
10 mg
产品信息
概述| 货号 | 15503-10mg |
| 描述 | Fidaxomycin is a natural macrocyclic antibiotic that inhibits RNA polymerase with selectivity for Gram-positive bacteria over Gram-negative bacteria (IC50s = 0.4 and 6 μM, respectively).1 It has potent antibacterial activity against most Gram-positive bacteria and effectively targets the Gram-positive C. difficile (MIC = 12 ng/ml).1 Orally administered fidaxomycin exhibits minimal systemic bioavailability resulting in maximal gastrointestinal tract distribution.1 Fidaxomycin is effective in clearing C. difficile infections while sparing Gram-negative bacteria in the gut.2,3 |
| 别名 | Clostomicin B1;Difimicin;Lipiarmycin;OPT-80;PAR-101;Tiacumicin B; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Srivastava, A.,Talaue, M.,Liu, S., et al. New target for inhibition of bacterial RNA polymerase: "Switch region". Curr.Opin.Microbiol. 14(5), 532-543 (2011).
2.Louie, T.J.,Emery, J.,Krulicki, W., et al. OPT-80 eliminates Clostridium difficile and is sparing of Bacteroides species during treatment of C. difficile infection. Antimicrobial Agents and Chemotherapy 53(1), 261-263 (2009).
3.Louie, T.J.,Miller, M.A.,Mullane, K.M., et al. Fidaxomicin versus vancomycin for Clostridium difficile infection. New England Journal of Medicine 364(5), 422-431 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 1058 |
| 分子式 | C52H74Cl2O18 |
| CAS号 | 873857-62-6 |
| 稳定性 | ≥ 2 years |
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