| 货号 | 15428-10mg |
| 描述 | Lamotrigine is an inhibitor of voltage-gated sodium channels (Nav), blocking human Nav1.2, Nav1.5, and Nav1.8 with IC50 values of 10, 62, and 96 μM, respectively.1,2 Presumably through this action, lamotrigine acts as an anticonvulsant and has applications in many diseases that feature seizures, including epilepsy and autism spectrum disorder.3,4 |
| 别名 | BW 430C;Epilepax;Lamictal;LTG; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Drizin, I.,Gregg, R.J.,Scanio, M.J., et al. Discovery of potent furan piperazine sodium channel blockers for treatment of neuropathic pain. Bioorganic & Medicinal Chemistry 16(12), 6379-6386 (2008). 2.Parker, M.H.,Smith-Swintosky, V.L.,McComsey, D.F., et al. Novel, broad-spectrum anticonvulsants containing a sulfamide group: Advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into human clinical studies. Journal of Medicinal Chemistry 52(23), 7528-7536 (2009). 3.Benbadis, S.R. and Tatum, W.O.I. Advances in the treatment of epilepsy. American Family Physician 64(1), 91-98 (2001). 4.Frye, R.E.,Rossignol, D.,Casanova, M.F., et al. A review of traditional and novel treatments for seizures in autism spectrum disorder: Findings from a systematic review and expert panel. Front.Public Health 1, 31 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 256.1 |
| 分子式 | C9H7Cl2N5 |
| CAS号 | 84057-84-1 |
| 稳定性 | ≥ 2 years |
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