Brimonidine (tartrate)
货号：
15426-10mg 基本售价：
630.0 元 规格：
10 mg
产品信息
概述| 货号 | 15426-10mg |
| 描述 | Brimonidine is a selective α2-adrenergic receptor agonist that lowers intraocular pressure by decreasing aqueous humor synthesis and increasing drainage through uveoscleral outflow.1 By stimulating α2-adrenergic receptors coupled to their G proteins (Ki = 183 nM), brimonidine inhibits adenylate cyclase activity and reduces cAMP.2 Furthermore, at 1 mg/kg/day brimonidine has been shown to protect rat retinal ganglion cells against glutamate excitotoxicity by inhibiting glutamate release and blocking the upregulation of NDMA receptor 1 and 2A protein expression.3 |
| 别名 | AGN 190342LF;Alphagan P; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Toris, C.B.,Camras, C.B. and Yablonski, M.E. Acute versus chronic effects of brimonidine on aqueous humor dynamics in ocular hypertensive patients. American Journal of Ophthalmology 128(1), 8-14 (1999).
2.Bylund, D.B.,Gerety, M.E.,Happe, H.K., et al. A robust GTP-induced shift in α2-adrenoceptor agonist affinity in tissue sections from rat brain. Journal of Neuroscience Methods 105(2), 159-166 (2001).
3.Lee, D.,Kim, K.Y.,Noh, Y.H., et al. Brimonidine blocks glutamate excitotoxicity-induced oxidative stress and preserves mitochondrial transcription factor A in ischemic retinal injury. PLoS One 7(10), e47098 (2012).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 442.2 |
| 分子式 | C11H10BrN5 • C4H6O6 |
| CAS号 | 70359-46-5 |
| 稳定性 | ≥ 2 years |
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