| 货号 | 15314-50mg |
| 描述 | Cotinine is a minor alkaloid found in tobacco plants and is a major metabolite of nicotine.1 It has a long pharmacological half-life (15-19 hours) compared to that of nicotine (2-3 hours) and is often used as a biomarker to detect tobacco use.2,3,4 Cotinine binds nicotinic- and muscarinic-type acetylcholine receptors with minimal receptor desensitization and demonstrates antipsychotic drug-like properties in behavioral models, neuroprotective properties in neurodegenerative disease models, and enhances attention in a delayed matching-to-sample task.2 |
| 别名 | NIH 10498; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Clemens, K.J.,Caillé, S.,Stinus, L., et al. The addition of five minor tobacco alkaloids increases nicotine-induced hyperactivity, sensitization and intravenous self-administration in rats. Int.J.Neuropsychopharmacol. 12(10), 1355-1366 (2009). 2.Terry, A.V., Jr.,Hernandez, C.M.,Hohnadel, E.J., et al. Cotinine, a neuroactive metabolite of nicotine: Potential for treating disorders of impaired cognition. CNS Drug Rev. 11(3), 229-252 (2005). 3.Jacob, P., III,Yu, L.,Shulgin, A.T., et al. Minor tobacco alkaloids as biomarkers for tobacco use: Comparison of users of cigarettes, smokeless tobacco, cigars, and pipes. Am.J.Public Health 89(5), 731-736 (1999). 4.Murphy, S.E.,Link, C.A.,Jensen, J., et al. A comparison of urinary biomarkers of tobacco and carcinogen exposure in smokers. Cancer Epidemiology, Biomarkers & Prevention 13(10), 1617-1623 (2004). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 176.2 |
| 分子式 | C10H12N2O |
| CAS号 | 486-56-6 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |