(±)-Octanoylcarnitine (chloride)
货号：
15048-25mg 基本售价：
630.0 元 规格：
25 mg
产品信息
概述| 货号 | 15048-25mg |
| 描述 | Carnitine facilitates the transport of acyl units across the inner mitochondrial membrane. Fatty acid esters of carnitine (acylcarnitines) have been shown to inhibit the oxidation of long chain fatty acids by interfering with the mitochondrial carnitine:acylcarnitine exchange system.1 (±)-Octanoylcarnitine is a carnitine ester that inhibits carnitine-acylcarnitine translocase with an IC50 value of 33 μM.1 Medium-chain acyl-CoA dehydrogenase deficiency, a risk factor for sudden unexpected infant death, leads to the accumulation of (±)-octanoylcarnitine in the blood.2 Thus, analysis of neonatal blood concentrations of (±)-octanoylcarnitine by tandem mass spectrometry has been used as part of a standard newborn screening program as a biomarker of this deficiency.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Baillet, L.,Mullur, R.S.,Esser, V., et al. Elucidation of the mechanism by which (+)-acylcarnitines inhibit mitochondrial fatty acid transport. The Journal of Biological Chemisty 275(42), 36766-36768 (2000).
2.Khalid, J.M.,Oerton, J.,Besley, G., et al. Relationship of octanoylcarnitine concentrations to age at sampling in unaffected newborns screened for medium-chain acyl-CoA dehydrogenase deficiency. Clinical Chemistry 56(6), 1015-1021 (2010).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 323.9 |
| 分子式 | C15H30NO4 • Cl |
| CAS号 | 14919-35-8 |
| 稳定性 | ≥ 2 years |
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