| 货号 | 14826-10mg |
| 描述 | Calmodulin is a calcium-dependent protein that regulates the activity of a diverse array of enzymes, ion channels, and other proteins and thus has diverse roles in cell function.1,2 W-7 is a cell-permeable antagonist of calmodulin (Ki = 11 μM).3,4 Two molecules of W-7 bind to calcium-binding domains in each calmodulin molecule, blocking its interaction with target proteins.3 W-7 also associates, at lower affinities, with calcium-binding domains of other proteins, including troponin C and myosin light chain kinase (Ki = 70 and 300 μM, respectively).5,6,7 |
| 别名 | NSC 683545; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Benaim, G. and Villalobo, A. Phosphorylation of calmodulin. Functional implications. European Journal of Biochemistry 269(15), 3619-3631 (2002). 2.Chin, D. and Means, A.R. Calmodulin: A prototypical calcium sensor. Trends in Cell Biology 10(8), 322-328 (2000). 3.Osawa, M.,Swindells, M.B.,Tanikawa, J., et al. Solution structure of calmodulin-W-7 complex: The basis of diversity in molecular recognition. Journal of Molecular Biology 276(1), 165-176 (1998). 4.Hidaka, H.,Sasaki, Y.,Tanaka, T., et al. N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation. Proceedings of the National Academy of Sciences of the United States of America 78(7), 4354-4357 (1981). 5.Adhikari, B.B. and Wang, K. Interplay of troponin- and myosin-based pathways of calcium activation in skeletal and cardiac muscle: The use of W7 as an inhibitor of thin filament activation. Biophysical Journal 86(1), 359-370 (2004). 6.Hoffman, R.M.B. and Sykes, B.D. Structure of the inhibitor W7 bound to the regulatory domain of cardiac troponin C. Biochemistry 48(24), 5541-5552 (2009). 7.Zimmer, M. and Hofmann, F. Calmodulin antagonists inhibit activity of myosin light-chain kinase independent of calmodulin. European Journal of Biochemistry 142(2), 393-397 (1984). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 377.3 |
| 分子式 | C16H21ClN2O2S • HCl |
| CAS号 | 61714-27-0 |
| 稳定性 | ≥ 2 years |
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