| 货号 | 14795-5mg |
| 描述 | In the classical pathway of NF-κB activation, phosphorylation of the inhibitor of NF-κB (IκBα) releases the inhibitor from NF-κB, allowing IκBα degradation and NF-κB activation and nuclear import.1 BAY 11-7085 is an irreversible inhibitor of IκBα phosphorylation, preventing activation of NF-κB by cytokines and lipopolysaccharide (IC50 = 10 μM).2 It blocks gene expression that is regulated through the classical pathway of NF-κB activation and in this way blocks apoptosis, cell adhesion, and inflammation.2,3,4 BAY 11-7085 is also used to study IκBα actions that are independent of NF-κB signaling.5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Wajant, H. and Scheurich, P. TNFR1-induced activation of the classical NF-κB pathway. FEBS Journal 278(6), 862-876 (2011). 2.Pierce, J.W.,Schoenleber, R.,Jesmok, G., et al. Novel inhibitors of cytokine-induced IκBα phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. The Journal of Biological Chemisty 272(34), 21096-21103 (1997). 3.Scaife, C.L.,Kuang, J.,Wills, J.C., et al. Nuclear factor κB inhibitors induce adhesion-dependent colon cancer apoptosis: Implications for metastasis. Cancer Research 62(23), 6870-6878 (2002). 4.Di Giuseppe, M.,Gambelli, F.,Hoyle, G.W., et al. Systemic inhibition of NF-κB activation protects from silicosis. PLoS One 4(5), e5689 (2009). 5.Hu, X.,Janssen, W.E.,Moscinski, L.C., et al. An IκBα inhibitor causes leukemia cell death through a p38 MAP kinase-dependent, NF-κB-independent mechanism. Cancer Research 61(16), 6290-6296 (2001). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 249.3 |
| 分子式 | C13H15NO2S |
| CAS号 | 196309-76-9 |
| 稳定性 | ≥ 2 years |
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