| 货号 | 14791-1mg |
| 描述 | The liver x receptors (LXRα and LXRβ) are nuclear hormone receptors whose native ligands, oxysterols, induce the expression of genes involved in cholesterol and fatty acid metabolism.1 27-hydroxy Cholesterol, a sterol 27-hydroxylase-mediated cholesterol hydroxylation product, activates LXRα and LXRβ in vitro with EC50 values of 85 and 71 nM, respectively, and is a potent suppressor of cholesterol biosynthesis.2,3 25(S)-27 hydroxy Cholesterol is the less predominant-occurring (~20%) stereoisomer of the endogenous oxysterol 27-hydroxy cholesterol.4,5 |
| 别名 | (25S)-26-hydroxy cholesterol; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Zhang, Y. and Mangelsdorf, D.J. LuXuRies of lipid homeostasis: The unity of nuclear hormone receptors, transcription regulation, and cholesterol sensing. Molecular Interventions 2(2), 78-87 (2002). 2.Fu, X.,Menke, J.G.,Chen, Y., et al. 27-Hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells. The Journal of Biological Chemisty 276(42), 38378-38387 (2001). 3.Axelson, M. and Larsson, O. Low density lipoprotein (LDL) cholesterol is converted to 27-hydroxycholesterol in human fibroblasts. J.Bio.Chem. 270 (25), 15102-15110 (1995). 4.Javitt, N.B. 26-Hydroxycholesterol: Synthesis, metabolism, and biologic roles. Journal of Lipid Research 31, 1527-1533 (1990). 5.Javitt, N.B. 25R,26-Hydroxycholesterol revisited: Synthesis, metabolism, and biologic roles. Journal of Lipid Research 43, 665-670 (2002). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 402.7 |
| 分子式 | C27H46O2 |
| CAS号 | 56845-83-1 |
| 稳定性 | ≥ 2 years |
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