AMPK activator
货号：
14741-1mg 基本售价：
630.0 元 规格：
1 mg
产品信息
概述| 货号 | 14741-1mg |
| 描述 | AMPK activator is an indirect activator of AMP-activated protein kinase, AMPK (EC50 = 11.7 μM).1 It is thought to activate AMPK by inhibiting mitochondrial complex I, producing an increase in AMP levels.1 AMPK activator stimulates glucose uptake in L6 myocytes and promotes phosphorylation of acetyl-CoA carboxylase, a known target of AMPK.1 AMPK activator also decreases blood glucose concentrations in female Zucker diabetic rats, demonstrating its utility in whole animals.1 At 50 μM, it inhibits the growth of multiple myeloma cells.2 AMPK activator induces phosphorylation of raptor in PC3 prostate cancer cells, down-regulating mTORC1 signaling and reducing survivin expression.3 |
| 别名 | D942; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kosaka, T.,Okuyama, R.,Sun, W., et al. Identification of molecular target of AMP-activated protein kinase activator by affinity purification and mass spectrometry. Analytical Chemistry 77(7), 2050-2055 (2005).
2.Baumann, P.,Mandl-Weber, S.,Emmerich, B., et al. Activation of adenosine monophosphate activated protein kinase inhibits growth of multiple myeloma cells. Experimental Cell Research 313(16), 3592-3603 (2007).
3.Roca, H.,Varsos, Z.S. and Pienta, K.J. CCL2 is a negative regulator of AMP-activated protein kinase to sustain mTOR complex-1 activation, survivin expression, and cell survival in human prostate cancer PC3 cells. Neoplasia 11(12), 1309-1317 (2009).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 368.4 |
| 分子式 | C22H21FO4 |
| CAS号 | 849727-81-7 |
| 稳定性 | ≥ 2 years |
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