(S)-10-hydroxy-Camptothecin
货号：
14635-25mg 基本售价：
630.0 元 规格：
25 mg
产品信息
概述| 货号 | 14635-25mg |
| 描述 | DNA topoisomerases relax supercoiled DNA during replication, transcription, recombination, repair, and chromosome condensation. The relaxation of DNA supercoiling by topoisomerase I at single-strand breaks represents a target for anticancer agents to intercalate between DNA base pairs, leading to the activation of apoptotic and cell cycle arrest pathways.1 (S)-10-hydroxy-Camptothecin is an inhibitor of topoisomerase I originally isolated from the Chinese tree C. acuminata. It is a member of the camptothecin family that demonstrates less toxicity than its parent compound.2 (S)-10-hydroxy-Camptothecin has strong anti-tumor activity against a wide range of experimental tumors including L1210 leukemia cells (IC50 = 1.15 μM).2 In vitro treatment of human HepG2 cells with 5-20 μM (S)-10-hydroxy-camptothecin results in cell cycle arrest at the G2/M phase.3 |
| 别名 | ChEMBL 273862;NSC 107124; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Drwal, M.N.,Agama, K.,Wakelin, L.P.G., et al. Exploring DNA topoisomerase I ligand space in search of novel anticancer agents. PLoS One 6(9), 1-12 (2011).
2.Yu, P.,Xia, L.,Zhao, J., et al. Synthesis and preliminary anticancer evaluation of 10-hydroxycamptothecin analogs. Biological and Pharmaceutical Bullentin 35(8), 1295-1299 (2012).
3.Zhang, X.W.,Jiang, J.F. and Xu, B. Differentiation-inducing action of 10-hydroxycamptothecin on human hepatoma Hep G2 cells. Acta.Pharmacol.Sin. 21(4), 364-368 (2000).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 364.4 |
| 分子式 | C20H16N2O5 |
| CAS号 | 19685-09-7 |
| 稳定性 | ≥ 2 years |
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