Philanthotoxin 74 (hydrochloride)
货号：
14607-1mg 基本售价：
630.0 元 规格：
1 mg
产品信息
概述| 货号 | 14607-1mg |
| 描述 | Philanthotoxin 74 (PhTx-74) is a synthetic analog of the naturally-occurring wasp venom toxin philanthotoxin-4,3,3. It is a subtype-selective AMPA receptor antagonist that inhibits homomeric GluR1 and GluR3 as well as heteromeric GluR1/2 receptors (80-100% of glutamate-evoked currents inhibited at 100 µM). It exhibits minimal to no effect on monomeric GluR2 or heteromeric GluR2/3 receptors at concentrations up to 500 µM.1 PhTx-74 inhibits the GluR5(Q) receptor with a Ki value of 0.29 µM.2 |
| 别名 | PhTx-74; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Nilsen, A. and England, P.M. A subtype-selective, use-dependent inhibitor of native AMPA receptors. Journal of the American Chemical Society 129(16), 4902-4903 (2007).
2.Kromann, H.,Krikstolaityte, S.,Andersen, A.J., et al. Solid-phase synthesis of polyamine toxin analogues: Potent and selective antagonists of Ca2+-permeable AMPA receptors. Journal of Medicinal Chemistry 45(26), 5745-5754 (2002).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 22 |
| 纯度 | ≥98% |
| 计算分子量 | 507.5 |
| 分子式 | C24H42N4O3 • 2HCl |
| CAS号 | 1227301-51-0 |
| 稳定性 | ≥ 6 months |
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