GSK2578215A
货号：
14603-5mg 基本售价：
630.0 元 规格：
5 mg
产品信息
概述| 货号 | 14603-5mg |
| 描述 | GSK2578215A is a potent inhibitor of leucine-rich repeat kinase 2 (LRRK2; IC50 = 8.9 nM) that also inhibits the G2019S mutant of LRRK2 (IC50 = 10.1 nM).1 It displays selectivity for LRRK2 over a panel of 460 other kinases. GSK2578215A prevents phosphorylation of both wild-type and G2019S LRRK2 in mouse spleen and kidney, but not in brain, following intraperitoneal injection of 100 mg/kg.1 GSK2578215A induces protective autophagy in SH-SY5Y cells and blocks LRRK2-dependent Na+/Ca2+ exchanger activity in dendritic cells.2,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Reith, A.D.,Bamborough, P.,Jandu, K., et al. GSK2578215A; a potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor. Bioorg. Med. Chem. Lett. 22(17), 5625-5629 (2012).
2.Saez-Atienzar, S.,Bonet-Ponce, L.,Blesa, J.R., et al. The LRRK2 inhibitor GSK2578215A induces protective autophagy in SH-SY5Y cells: Involvement of Drp-1-mediated mitochondrial fission and mitochondrial-derived ROS signaling. Cell Death Dis. 14(5), e1368 (2014).
3.Yan, J.,Almilaji, A.,Schmid, E., et al. Leucine-rich repeat kinase 2-sensitive Na+/Ca2+ exchanger activity in dendritic cells. FASEB J. 29(5), 1701-1710 (2015).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 399.4 |
| 分子式 | C24H18FN3O2 |
| CAS号 | 1285515-21-0 |
| 稳定性 | ≥ 2 years |
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