| 货号 | 14406-5mg |
| 描述 | Sodium-hydrogen exchangers (NHE) are involved in maintaining sodium and pH balance in a variety of tissues. They are also known as sodium-hydrogen antiporters and solute carrier family 9 members. 5-(N-ethyl-N-isopropyl)-Amiloride (EIPA) is a potent inhibitor of several NHE isoforms, inhibiting NHE1, NHE2, NHE3, and NHE5 with Ki values of 0.02, 0.5, 2.4, and 0.42 μM, respectively.1,2 It less effectively inhibits NHE4 (IC50 ≥10 μM).1 EIPA is commonly used at a concentration of 5-10 μM to inhibit cellular HNE activity.3,4 |
| 别名 | EPIA;L-593,754;MH 12-43; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Masereel, B.,Pochet, L. and Laeckmann, D. An overview of inhibitors of Na+/H+ exchanger. Eur. J. Med. Chem. 38(6), 547-554 (2003). 2.Attaphitaya, S.,Park, K. and Melvin, J.E. Molecular cloning and functional expression of a rat Na+/H+ exchanger (NHE5) highly expressed in brain. The Journal of Biological Chemisty 274(7), 4383-4388 (1999). 3.Hwang, S.M.,Koo, N.Y.,Jin, M., et al. Intracellular acidification is associated with changes in free cytosolic calcium and inhibition of action potentials in rat trigeminal ganglion. The Journal of Biological Chemisty 286(3), 1719-1729 (2011). 4.Xue, L.,Aihara, E.,Wang, T.C., et al. Trefoil factor 2 requires Na/H exchanger 2 activity to enhance mouse gastric epithelial repair. The Journal of Biological Chemisty 286(44), 38375-38382 (2011). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 299.8 |
| 分子式 | C11H18ClN7O |
| CAS号 | 1154-25-2 |
| 稳定性 | ≥ 2 years |
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