| 货号 | 14323-5mg |
| 描述 | Tanshinone IIA (TSA) is a major lipophilic component of extracts from the root of S. miltiorrhiza, used widely in Chinese herbal medicine. It has anti-inflammatory activity, inhibiting production of TNF-α, IL-1β, IL-6, NO, INFγ, and expression of iNOS, and IL-12.1,2 It blocks human aortic smooth muscle cell migration, inhibits MMP-9 activity, and interferes with PI3K/Akt and ERK1/2 signaling pathways.3 It is cytotoxic to various cancer cells including A549 lung cancer cells and leukemia cells.4,5Reduction of TSA by NAD(P)H:quinone oxidoreductase (NQO1) generates an unstable intermediate resulting in reactive oxygenase species-mediated apoptotic cell death.6 |
| 别名 | NSC 686518;NSC 686519;TSA; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Jang, S.I.,Jeong, S.I.,Kim, K.J., et al. Tanshinone IIA from Salvia miltiorrhiza inhibits inducible nitric oxide synthase expression and production of TNF-α, IL-1β and IL-6 in activated RAW 264.7 cells. Planta Medica 69(11), 1057-1059 (2003). 2.Kang, B.Y.,Chung, S.W.,Kim, S.H., et al. Inhibition of interleukin-12 and interferon-γ production in immune cells by tanshinones from Salvia miltiorrhiza. Immunopharmacology 49(3), 355-361 (2000). 3.Jin, U.H.,Suh, S.J.,Chang, H.W., et al. Tanshinone IIA from Salvia miltiorrhiza BUNGE inhibits human aortic smooth muscle cell migration and MMP-9 activity through AKT signaling pathway. J.Cell Biochem. 104(1), 15-26 (2008). 4.Chiu, T.L. and Su, C.C. Tanshinone IIA induces apoptosis in human lung cancer A549 cells through the induction of reactive oxygen species and decreasing the mitochondrial membrane potential. International Journal of Molecular Medicine 25(2), 231-236 (2010). 5.Sung, H.J.,Choi, S.M.,Yoon, Y., et al. Tanshinone IIA, an ingredient of Salvia miltiorrhiza BUNGE, induces apoptosis in human leukemia cell lines through the activation of caspase-3. Experimental and Molecular Medicine 31(4), 174-178 (1999). 6.Liu, F.,Yu, G.,Wang, G., et al. An NQO1-initiated and p53-independent apoptotic pathway determines the anti-tumor effect of Tanshinone IIA against non-small cell lung cancer. PLoS One 7(7), 42138 (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥97% |
| 计算分子量 | 294.3 |
| 分子式 | C19H18O3 |
| CAS号 | 568-72-9 |
| 稳定性 | ≥ 2 years |
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