Chloroquine (phosphate)
货号：
14194-25g 基本售价：
630.0 元 规格：
25 g
产品信息
概述| 货号 | 14194-25g |
| 描述 | Chloroquine is an aminoquinoline antimalarial compound that acts by preventing detoxification of hematin within the Plasmodium digestive vacuole.1,2 Although it has lost its antimalarial efficacy through the development of mutations within the P. falciparum chloroquine resistance transporter, chloroquine is widely used as an autophagy inhibitor that can prevent autophagosome fusion with lysosomes and inhibit lysosomal acidification.2 It has been used in co-treatment with etoposide (Item No. 12092) to inhibit adrenocortical tumor cell growth and to inhibit Cdk2 and ERK activity.3 |
| 别名 | Aralen;DL-Chloroquine;NSC 14050; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hwang, J.,Bitarakwate, E.,Pai, M., et al. Chloroquine or amodiaquine combined with sulfadoxine-pyrimethamine for uncomplicated malaria: A systematic review. Trop.Med.Int.Health 11(6), 789-799 (2006).
2.Chen, P.M.,Gombart, Z.J. and Chen, J.W. Chloroquine treatment of ARPE-19 cells leads to lysosome dilation and intracellular lipid accumulation: Possible implications of lysosomal dysfunction in macular degeneration. Cell.Biosci. 1(1), (2011).
3.Chen, T.Y.,Syu, J.S.,Lin, T.C., et al. Chloroquine alleviates etoposide-induced centrosome amplification by inhibiting CDK2 in adrenocortical tumor cells. Onconogenesis 4, (2015).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 515.9 |
| 分子式 | C18H26ClN3 • 2H3PO4 |
| CAS号 | 50-63-5 |
| 稳定性 | ≥ 2 years |
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