| 货号 | 14162-5mg |
| 描述 | Glycitein is an O-methylated isoflavone that comprises 5-10% of the total isoflavones in soy food products. This phytoestrogen is reported to have weak estrogenic activity, displacing estradiol binding at the estrogen receptor in vitro with an IC50 value of 3.94 μM.1 It suppresses the proliferation of osteoblasts and promotes differentiation from its progenitor.2 It has also been used to attenuate proliferation (10 μM) of aortic smooth muscle cells related to atherosclerotic vascular change in stroke-prone hypertensive rats and to protect against beta amyloid (Aβ)-induced toxicity and oxidative stress (100 μg/ml) in C. elegans expressing human Aβ.3,4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Song, T.T.,Hendrich, S. and Murphy, P.A. Estrogenic activity of glycitein, a soy isoflavone. Journal of Agricultural and Food Chemistry 47, 1607-1610 (1999). 2.Yoshida, H.,Teramoto, T.,Ikeda, K., et al. Glycitein effect on suppressing the proliferation and stimulating the differentiation of osteoblastic MC3T3-E1 cells. Bioscience, Biotechnology, and Biochemistry 65(5), 1211-1213 (2001). 3.Pan, W.,Ikeda, K.,Takebe, M., et al. Genistein, daidzein and glycitein inhibit growth and DNA synthesis of aortic smooth muscle cells from stroke-prone spontaneously hypertensive rats. Journal of Nutrition 131(4), 1154-1158 (2001). 4.Gutierrez-Zepeda, A.,Santell, R.,Wu, Z., et al. Soy isoflavone glycitein protects againstβamyloid-induced toxicity and oxidative stress in transgenic Caenorhabditis elegans. BMC Neuroscience 6(54), (2005). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 284.3 |
| 分子式 | C16H12O5 |
| CAS号 | 40957-83-3 |
| 稳定性 | ≥ 2 years |
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