Indirubin
货号：
14155-5mg 基本售价：
630.0 元 规格：
5 mg
产品信息
概述| 货号 | 14155-5mg |
| 描述 | Indirubin is a natural product originally extracted from roots and leaves of the Indigo plant (I. tinctoria) used in traditional Chinese medicine for anti-inflammatory, anti-tumor, and neuroprotective effects. Indirubin inhibits glycogen synthase kinase-3 (IC50 = 2.5 μM) and cyclin-dependent kinases 1 and 5 (IC50 = 10 μM for both isoforms).1,2,3 |
| 别名 | C.I. 73200;Couroupitine B;Indigopurpurin;NSC 105327; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ferandin, Y.,Bettayeb, K.,Kritsanida, M., et al. 3-Substituted 7-halogenoindirubins, a new class of cell death inducing agents. Journal of Medicinal Chemistry 49, 4638-4649 (2006).
2.Guengerich, F.P.,Sorrells, J.L.,Schmitt, S., et al. Generation of new protein kinase inhibitors utilizing cytochrome P450 mutant enzymes for indigoid synthesis. Journal of Medicinal Chemistry 47, 3236-3241 (2004).
3.McGovern, S.L. and Shoichet, B.K. Kinase inhibitors: Not just for kinases anymore. Journal of Medicinal Chemistry 46, 1478-1483 (2003).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 262.3 |
| 分子式 | C16H10N2O2 |
| CAS号 | 479-41-4 |
| 稳定性 | ≥ 2 years |
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