| 货号 | 14154-50mg |
| 描述 | Floxuridine is a prodrug that is rapidly catabolized in vivo to 5-fluorouracil when administered by rapid injection.1 In addition, floxuridine inhibits thymidylate synthase (EC50 = 0.6 nM), interfering with DNA synthesis.2,3 It has been used to treat various cancers, particularly metastases to the liver.4 |
| 别名 | 5-FDU;5-Fluorodeoxyuridine;NSC 26740;NSC 27640; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Ozawa, S.,Hamada, M.,Murayama, N., et al. Cytosolic and microsomal activation of doxifluridine and tegafur to produce 5-fluorouracil in human liver. Cancer Chemotherapy and Pharmacology 50, 454-458 (2002). 2.Ferguson, P.J.,Collins, O.,Dean, N.M., et al. Antisense down-regulation of thymidylate synthase to suppress growth and enhance cytotoxicity of 5-FUdR, 5-FU and Tomudex in HeLa cells. British Journal of Pharmacology 127(8), 1777-1786 (1999). 3.Tzioumaki, N.,Manta, S.,Tsoukala, E., et al. Synthesis and biological evaluation of unsaturated keto and exomethylene D-arabinopyranonucleoside analogs: Novel 5-fluorouracil analogs that target thymidylate synthase. European Journal of Medicinal Chemistry 46(4), 993-1005 (2011). 4.Power, D.G. and Kemeny, N.E. The role of floxuridine in metastatic liver disease. Molecular Cancer Therapeutics 8(5), 1015-1025 (2009). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 246.2 |
| 分子式 | C9H11FN2O5 |
| CAS号 | 50-91-9 |
| 稳定性 | ≥ 2 years |
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