KC7F2
货号：
14123-5mg 基本售价：
630.0 元 规格：
5 mg
产品信息
概述| 货号 | 14123-5mg |
| 描述 | Hypoxia-inducible factor-1 (HIF-1) is a heterodimeric transcription factor composed of a HIF-1α subunit and HIF-1β subunit. The HIF-1α subunit is regulated by cellular oxygen levels and therefore plays an important role in maintaining cellular oxygen homeostasis.1,2 KC7F2 is an inhibitor of HIF-1α protein translation, but not transcription, that suppresses phosphorylation of two key regulators of protein synthesis, eukaryotic translation initiation factor 4E binding protein 1 (4EBP1) and p70 S6 kinase (S6K).3 It inhibits hypoxia-induced expression of several HIF target genes, such as carbonic anhydrase IX, matrix metalloproteinase 2, enolase 1, and endothelin 1. KC7F2 is cytotoxic to a variety of cancer cell lines with an IC50 value of 15-25 µM.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Wang, G.L.,Jiang, B.H.,Rue, E.A., et al. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proceedings of the National Academy of Sciences of the United States of America 92, 5510-5514 (1995).
2.Safran, M. and Kaelin, W.G., Jr. HIF hydroxylation and the mammalian oxygen-sensing pathway. Journal of Clinical Investigation 111, 779-783 (2003).
3.Narita, T.,Yin, S.,Gelin, C.F., et al. Identification of a novel small molecule HIF-1α translation inhibitor. Clinical Cancer Research 15(19), 6128-6136 (2009).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 570.4 |
| 分子式 | C16H16Cl4N2O4S4 |
| CAS号 | 927822-86-4 |
| 稳定性 | ≥ 2 years |
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