| 货号 | 13040-1mg |
| 描述 | Biotin-azide is a form of biotin with a terminal azide group. It is used to add biotin to other molecules that bear either an alkyne group, through click chemistry, or a phosphine group, using Staudinger ligation.1,2 Biotin-azide has been commonly used to biotin-tag alkynylated lipids, particularly those associated with proteins through post-translational modification.3,4,1 It can also be used to biotin-tag proteins, lipids, carbohydrates, and nucleic acids that have been modified with alkyne or phosphine groups.5,6,7,8 |
| 别名 | Azido-biotin;Click Tag™ Biotin-azide; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Yap, M.C.,Kostiuk, M.A.,Martin, D.D.O., et al. Rapid and selective detection of fatty acylated proteins using ω-alkynyl-fatty acids and click chemistry. Journal of Lipid Research 51, 1566-1580 (2010). 2.Zhang, J.,Li, S.,Zhang, D., et al. Reductive ligation mediated one-step disulfide formation of S-nitrosothiols. Organic Letters 12(18), 4208-4211 (2010). 3.Kim, H.Y.H.,Tallman, K.A.,Liebler, D.C., et al. An azido-biotin reagent for use in the isolation of protein adducts of lipid-derived electrophiles by streptavidin catch and photorelease. Molecular & Cellular Proteomics 8(9), 2080-2089 (2009). 4.Yount, J.S.,Zhang, M.M., and Hang, H.C. Visualization and identification of fatty acylated proteins using chemical reporters. Curr.Protoc.Chem.Biol. 3(2), 65-79 (2011). 5.Ma, Y.,Zhang, H.,Gruzdys, V., et al. Azide-reactive liposome for chemoselective and biocompatible liposomal surface functionalization and glyco-liposomal microarray fabrication. Langmuir 27(21), 13097-13103 (2011). 6.Crump, C.J.,am Ende, C.W.,Ballard, T.E., et al. Development of clickable active site-directed photoaffinity probes for γ-secretase. Bioorganic & Medicinal Chemistry Letters 22(8), 2997-3000 (2012). 7.Sohn, C.H.,Agnew, H.D.,Lee, J.E., et al. Designer reagents for mass spectrometry-based proteomics: Clickable cross-linkers for elucidation of protein structures and interactions. Analytical Chemistry 84(6), 2662-2669 (2012). 8.Al-Shareffi, E.,Chaubard, J.L.,Leonhard-Melief, C., et al. 6-alkynyl fucose is a bioorthogonal analog for O-fucosylation of epidermal growth factor-like repeats and thrombospondin type-1 repeats by protein O-fucosyltransferases 1 and 2. Glycobiology 23(2), 188-198 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 326.4 |
| 分子式 | C13H22N6O2S |
| CAS号 | 908007-17-0 |
| 稳定性 | ≥ 2 years |
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