Anastrozole
货号：
11987-10mg 基本售价：
630.0 元 规格：
10 mg
产品信息
概述| 货号 | 11987-10mg |
| 描述 | Anastrozole is a third generation aromatase inhibitor that has been shown to effectively eliminate the conversion of androgens to estrogens in peripheral tissues.1,2 It inhibits human placental aromatase in vitro with an IC50 value of 15 nM and at doses 100–200 times its maximally effective aromatase inhibitory dose, does not interfere with the biosynthesis of other steroids, including cholesterol, cortisol, and aldosterone.3 Marketed under the trade name Arimidex™, anastrozole has been used to treat estrogen receptor-positive breast cancers in post-menopausal women.2 |
| 别名 | Anastrol;Arimidex™;ICI-D 1033;ZD 1033; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Burnett, A.F.,Bahador, A., and Amezcua, C. Anastrozole, an aromatase inhibitor, and medroxyprogesterone acetate therapy in premenopausal obese women with endometrial cancer: A report of two cases successfully treated without hysterectomy. Gynecologic Oncology 94, 832-834 (2004).
2.Smith, I.E., and Dowsett, M. Aromatase inhibitors in breast cancer. New England Journal of Medicine 348, 2431-2442 (2003).
3.Grimm, S.W., and Dyroff, M.C. Inhibition of human drug metabolizing cytochromes P450 by anastrozole, a potent and selective inhibitor of aromatase. Drug Metabolism and Disposition 25(5), 598-602 (1997).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 293.4 |
| 分子式 | C17H19N5 |
| CAS号 | 120511-73-1 |
| 稳定性 | ≥ 2 years |
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