| 货号 | 11912-5mg |
| 描述 | AP-18 is a channel blocker which reversibly inhibits TRPA1 (IC50s = 3.1 and 4.5 µM, human and mouse, respectively).1,2 It has minimal effect on TRPV1-4 or TRPM8.1 AP-18 has been used to study TRPA1 signaling in mice and rats as well as in vitro.1,3,4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Petrus, M.,Peier, A.M.,Bandell, M., et al. A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition. Molecular Pain 3, 40 (2007). 2.Fanger, C.M.,del Camino, D., and Moran, M.M. TRPA1 as an analgesic target. Open Drug Discov.J. 2, 64-70 (2010). 3.Chen, J.,Kim, D.,Bianchi, B.R., et al. Pore dilation occurs in TRPA1 but not in TRPM8 channels. Molecular Pain 5, 3 (2009). 4.Taylor-Clark, T.E.,Ghatta, S.,Bettner, W., et al. Nitrooleic acid, an endogenous product of nitrative stress, activates nociceptive sensory nerves via the direct activation of TRPA1. Molecular Pharmacology 75(4), 820-829 (2009). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 209.7 |
| 分子式 | C11H12ClNO |
| CAS号 | 55224-94-7 |
| 稳定性 | ≥ 2 years |
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