Vinblastine (sulfate)
货号：
11762-5mg 基本售价：
630.0 元 规格：
5 mg
产品信息
概述| 货号 | 11762-5mg |
| 描述 | Vinblastine, derived from C. roseus, also known as V. rosea, a Madagascar periwinkle, is an antimicrotubule drug used to treat certain cancers, including Hodgkin’s lymphoma, non-small cell lung, breast, head and neck, and testicular cancer. Like its chemical analog vincristine, vinblastine binds tubulin, inhibiting the assembly of microtubules and causing M phase-specific cell cycle arrest by disrupting microtubule assembly and proper formation of the mitotic spindle. It has been shown to inhibit steady-state tubulin addition to microtubules with a Ki value of 0.18 μM, inhibit B16 melanoma cell proliferation with an IC50 value of 1 nM, and produce complete inhibition of L-cell proliferation at 40 nM.1 Vinblastine is reported to be an effective component of certain chemotherapy regimens, particularly when used with bleomycin and methotrexate in vinblastine, bleomycin, and methotrexate combination chemotherapy for Stage IA or IIA Hodgkin lymphomas.2 |
| 别名 | 29060LE;Alkaban-AQ;Exal;NSC 49842;Rozevinsulfate;Velban®;Velsar;Vincaleukoblastinesulfate;VLB; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Jordan, M.A.,Himes, R.H., and Wilson, L. Comparison of the effects of vinblastine, vincristine, vindesine, and vinepidine on microtubule dynamics and cell proliferation in vitro. Cancer Research 45(6), 2741-2747 (1985).
2.Martinelli, G.,Cocorocchio, E.,Saletti, P.C., et al. Efficacy of vinblastine, bleomycin, methotrexate (VBM) combination chemotherapy with involved field radiotherapy in early stage (I-IIA) Hodgkin disease patients. Leukemia and Lymphoma 44(11), 1919-1923 (2003).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 909.1 |
| 分子式 | C46H58N4O9 • H2SO4 |
| CAS号 | 143-67-9 |
| 稳定性 | ≥ 2 years |
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