SL 0101-1
货号：
11704-500ug 基本售价：
630.0 元 规格：
500 ug
产品信息
概述| 货号 | 11704-500ug |
| 描述 | The p90 ribosomal S6 kinases (RSK) 1-4 are downstream members of the extracellular signal-regulated kinase (ERK)/MAPK cascade. SL 0101-1 is a kaempferol glycoside, isolated from the tropical plant F. refracta, that selectively inhibits RSK2 with an IC50 value of 89 nM (Ki = 1 μM) without interfering with upstream activators of RSK, including ERK, MEK, EGFR, and PKC.1 At 100 μM, SL 0101-1 inhibits the proliferation of MCF-7 breast cancer cells, arresting cells in the G1 phase of the cell cycle.1 SL 0101-1 has been used to characterize the intracellular signaling events associated with angiotensin II-induced tyrosine kinase activation with a concentration of 30 μM attenuating angiotensin II-induced cell proliferation.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Smith, J.A.,Poteet-Smith, C.E.,Xu, Y., et al. Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation. Cancer Research 65(3), 1027-1034 (2005).
2.Godeny, M.D., and Sayeski, P.P. ERK1/2 regulates ANG II-dependent cell proliferation via cytoplasmic activation of RSK2 and nuclear activation of elk1. American Journal of Physiology.Cell Physiology 291, C1308-C1317 (2006).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 516.5 |
| 分子式 | C25H24O12 |
| CAS号 | 77307-50-7 |
| 稳定性 | ≥ 2 years |
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