| 货号 | 11437-5mg |
| 描述 | Nigericin is an antibiotic derived from S. hygroscopicus that acts as a potassium ionophore promoting K+/H+ exchange across mitochondrial membranes. Nigericin can be used as a research tool to disrupt intracellular H+ and K+ concentration, thus altering pH, membrane potential, and cell volume.1,2,3 At 10 μM, nigericin induces egress of T. gondii parasites by inducing efflux of K+.4 |
| 别名 | NSC 292567; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Alonso, M.A. and Carrasco, L. Relationship between membrane permeability and the translation capacity of human HeLa cells studied by means of the ionophore nigericin. European Journal of Biochemistry 118, 289-294 (1981). 2.Zotova, L.,Aleschko, M.,Sponder, G., et al. Novel components of an active mitochondrial K+/H+ exchange. The Journal of Biological Chemisty 285(19), 14399-14414 (2010). 3.Kucejova, B.,Kucej, M.,Petrezselyova, S., et al. A screen for nigericin-resistant yeast mutants revealed genes controlling mitochondrial volume and mitochondrial cation homeostasis. Genetics 171(2), 517-526 (2005). 4.Fruth, I.A. and Arrizabalaga, G. Toxoplasma gondii: Induction of egress by the potassium ionophore nigericin. Int.J.Parasitol. 37(14), 1559-1567 (2007). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 747 |
| 分子式 | C40H67O11 • Na |
| CAS号 | 28643-80-3 |
| 稳定性 | ≥ 2 years |
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