| 货号 | 11341-5mg |
| 描述 | Oligomycins are macrolides created by Streptomyces species that can be toxic to other organisms through their ability to inhibit mitochondrial membrane-bound ATP synthases. The mitochondrial F1FO ATP synthase can switch to an ATP hydrolase during ischemia, so that, under these conditions, inhibition by oligomycins will reduce ATP depletion rather than block ATP synthesis.1 Oligomycin complex is a mixture of oligomycins A (Item No. 11342), B (Item No. 11343), and C. Oligomycin A is a selective inhibitor of mitochondrial F1FO-ATP synthase that induces apoptosis in a variety of cell types (average GI50 = 270 nM).2,3,4 Oligomycin B is a nonselective inhibitor of ATP synthases. Oligomycin B (1-10 μM) can reduce the rate of ATP depletion in myocardial ischemia and decrease calcium-induced calcium release oscillation frequency of rat sensory neurons.1,5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Grover, G.J. and Malm, J. Pharmacological profile of the selective mitochondrial F1F0 ATP hydrolase inhibitor BMS-199264 in myocardial ischemia. Cardiovasc.Ther. 26, 287-296 (2008). 2.Salomon, A.R.,Voehringer, D.W.,Herzenberg, L.A., et al. Apoptolidin, a selective cytotoxic agent, is an inhibitor of F0F1-ATPase. Chemistry & Biology 8, 71-80 (2001). 3.Shin, Y.K.,Yoo, B.C.,Chang, H.J., et al. Down-regulation of mitochondrial F1F0-ATP synthase in human colon cancer cells with induced 5-fluorouracil resistance. Cancer Research 65(8), 3162-3170 (2005). 4.Laatsch, H.,Kellner, M.,Wolf, G., et al. Oligomycin F, a new immunosuppressive homologue of oligomycin A. Journal of Antibiotics 46(9), 1334-1341 (1993). 5.Jackson, J.G. and Thayer, S.A. Mitochondrial modulation of Ca2+-induced Ca2+-release in rat sensory neurons. Journal of Neurophysiology 96, 1093-1104 (2006). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% (Mixture of A, B, C) |
| CAS号 | 1404-19-9 |
| 稳定性 | ≥ 2 years |
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