7α,25-dihydroxy Cholesterol
货号：
11032-1mg 基本售价：
630.0 元 规格：
1 mg
产品信息
概述| 货号 | 11032-1mg |
| 描述 | GPR183 (also known as Epstein-Barr virus-induced gene 2) is an orphan G protein-coupled receptor (GPCR) that is highly expressed in spleen and is required for humoral immune responses, including B cell migration and T cell-dependent antibody production.1,2 7α,25-dihydroxy Cholesterol (7α,25-DHC) is a potent agonist of GPR183 that induces specific activation of the receptor with an EC50 value of 50 nM (Kd = 450 pM).1,2 At concentrations below 3 μM, it does not show any appreciable binding activity when tested against eight different nuclear hormone receptors including LXR and thirty-one different G protein-coupled receptors in a panel of reporter gene assays.2 7α,25-DHC can act as a potent chemokine, affecting migration of immune cells expressing GPR183 both in vitro(EC50 = 500 pM) and in vivo.1,2 |
| 别名 | 7α,25-DHC; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Liu, C.,Yang, X.V.,Wu, J., et al. Oxysterols direct B-cell migration through EB12. Nature 475(7357), 519-523 (2011).
2.Hannedouche, S.,Zhang, J.,Yi, T., et al. Oxysterols direct immune cell migration via EBI2. Nature 475(7357), 524-527 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 418.7 |
| 分子式 | C27H46O3 |
| CAS号 | 64907-22-8 |
| 稳定性 | ≥ 2 years |
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