| 货号 | 10960-5mg |
| 描述 | Bisdemethoxycurcumin (BDMC) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis, interacting with 1α,25-dihydroxy vitamin D3 to stimulate amyloid-β clearance by macrophages (optimal stimulation at 100 nM BDMC).1,2,3 More stable than curcumin in physiological media, BDMC suppresses proliferation in cancer cells.4,5 It down-regulates the transcriptional coactivator p300, suppressing the Wnt/β-catenin pathway, and inhibits LPS induction of iNOS expression.6,7 |
| 别名 | BDMC; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Fiala, M.,Liu, P.T.,Espinosa-Jeffrey, A., et al. Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer’s disease patients are improved by bisdemethoxycurcumin. Proceedings of the National Academy of Sciences of the United States of America 104(31), 12849-12854 (2007). 2.Masoumi, A.,Goldenson, B.,Ghirmai, S., et al. 1α,25-dihydroxyvitamin D3 interacts with curcuminoids to stimulate amyloid-β clearance by macrophages of Alzheimer’s disease patients. J.Alzheimers Dis. 17(3), 703-717 (2009). 3.Cashman, J.R.,Fhirmai, S.,Abel, K.J., et al. Immune defects in Alzheimer’s disease: New medications development. BMC Neuroscience 9(Suppl2), S13 (2008). 4.Sandur, S.K.,Pandley, M.K.,Ahn, K.S., et al. Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism. Carcinogenesis 28(8), 1765-1773 (2007). 5.Basile, V.,Ferrari, E.,Lazzari, S., et al. Curcumin derivatives: Molecular basis of their anti-cancer activity. Biochemical Pharmacology 78(10), 1305-1315 (2009). 6.Ryu, M.J.,Cho, M.,Song, J.Y., et al. Natural derivatives of curcumin attenuate the Wnt/β-catenin pathway through down-regulation of the transcriptional coactivator p300. Biochemical and Biophysical Research Communications 377(4), 1304-1308 (2008). 7.Mahattanadul, S.,Nakamura, T.,Panichayupakaranant, P., et al. Comparative antiulcer effect of bisdemethoxycurcumin and curcumin in a gastric ulcer model system. Phytomedicine 16(4), 342-351 (2009). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 308.3 |
| 分子式 | C19H16O4 |
| CAS号 | 24939-16-0 |
| 稳定性 | ≥ 2 years |
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