Ampkinone
货号：
10631-1mg 基本售价：
630.0 元 规格：
1 mg
产品信息
概述| 货号 | 10631-1mg |
| 描述 | AMP-activated protein kinase (AMPK) plays a role in energy metabolism and glucose homeostasis by monitoring the ratio of ATP to AMP. AMPK stimulates glucose uptake in skeletal muscle when activated during muscle contraction and exercise by the phosphorylation of threonine 172 (Thr172) by LKB19 and Ca2+/calmodulin-dependent kinase kinase. Ampkinone is a small molecule activator of AMPK. It has been shown to stimulate functional activation of AMPK via the phosphorylation at Thr172 in cultured L6 muscle cells with an EC50 value of 4.3 μM, enhancing glucose uptake by 3.2-fold.1 When given to diet-induced obese mice,10 mg/kg ampkinone up-regulated the activity of AMPK in liver and muscle, enhancing insulin sensitivity and increasing the oxidation of adipose tissues.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Oh, S.,Kim, S.J.,Hwang, J.H., et al. Antidiabetic and antiobesity effects of ampkinone (6f), a novel small molecule activator of AMP-activated protein kinase. Journal of Medicinal Chemistry 53, 7405-7413 (2010).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 505.5 |
| 分子式 | C31H23NO6 |
| CAS号 | 1233082-79-5 |
| 稳定性 | ≥ 2 years |
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