1-Stearoyl-2-Arachidonoyl-sn-Glycerol-d8
货号：
10009872-100ug 基本售价：
630.0 元 规格：
100 ug
产品信息
概述| 货号 | 10009872-100ug |
| 描述 | SAG-d8 contains eight deuterium atoms at the 5, 6, 8, 9, 11, 12, 14, and 15 positions. It is intended for use as an internal standard for the quantification of SAG by GC- or LC-mass spectrometry. Many protein kinase C (PKC) isoforms require activation via second messengers including Ca2+, diacylglycerol (DAG), and/or a phospholipid in order to phosphorylate target proteins, initiating a variety of important signaling cascades.11-Stearoyl-2-arachidonoyl-sn-glycerol (SAG) is a DAG that contains the ω-6 polyunsaturated fatty acid arachidonic acid in the sn-2 position and stearic acid in the sn-1 position of the glycerol backbone. It can potently activate PKCα, ε, and δ at nM concentrations.2 Independent of PKC signaling, SAG competitively binds to the Ras activator RasGRP with a Ki value of 4.49 µM in Jurkat T-cells.3 |
| 别名 | SAG-d8; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Bell, R.M., and Burns, D.J. Lipid activation of protein kinase C. The Journal of Biological Chemisty 266, 4661-4664 (1991).
2.Madani, S.,Hichami, A.,Legrand, A., et al. Implication of acyl chain diacylglycerols in activation of different isoforms of protein kinase C. The FASEB Journal 15, 2595-2601 (2001).
3.Madani, S.,Hichami, A.,Charkaoui-Malki, M., et al. Diacylglycerols containing ω-3 and ω-6 fatty acids bind to RasGRP and modulate MAP kinase activation. The Journal of Biological Chemisty 279(2), 1176-1183 (2004).
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| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥99% deuterated forms (d1-d8) |
| 计算分子量 | 653.1 |
| 分子式 | C41H64D8O5 |
| 稳定性 | ≥ 1 year |
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