Procyanidin B1
货号：
22411-1mg 基本售价：
616.0 元 规格：
1 mg
产品信息
概述| 货号 | 22411-1mg |
| 描述 | Procyanidin B1 is a polyphenol flavonoid existing as a dimer of (+)-catechin (Item No. 18644) and (-)-epicatechin (Item No. 11807). It inhibits hepatitis C virus RNA replication (EC50 = 72 µM), while (+)-catechin or (-)-epicatechin do not, up to concentrations of 200 µM.1 Pre-treatment with procyanidin B1 (40 µg/ml) decreases pERK1/2 expression in cells stimulated with lipopolysaccharide (LPS) and, at 10 µg/ml, prevents production of reactive oxygen species.2 It decreases TNF-α, phosphorylated p38 MAPK, and NF-κB levels following LPS administration, possibly by competing with LPS for binding to toll-like receptor 4.3 |
| 别名 | (-)-Epicatechin-(4β-8)-(+)-Catechin;Proanthocyanidin B1;Procyanidol B1; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Li, S.,Kodama, E.N.,Inoue, Y., et al. Procyanidin B1 purified from Cinnamomi cortex suppresses hepatitis C virus replication. Antivir. Chem. Chemother. 20(6), 239-248 (2010).
2.Terra, X.,Palozza, P.,Fernandez-Larrea, J., et al. Procyanidin dimer B1 and trimer C1 impair inflammatory response signalling in human monocytes. Free Radic. Res. 45(5), 611-619 (2011).
3.Xing, J.,Li, R.,Li, N., et al. Anti-inflammatory effect of procyanidin B1 on LPS-treated THP1 cells via interaction with the TLR4-MD-2 heterodimer and p38 MAPK and NF-κB signaling. Mol. Cell. Biochem. 407(1-2), 89-95 (2015).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 578.5 |
| 分子式 | C30H26O12 |
| CAS号 | 20315-25-7 |
| 稳定性 | ≥ 2 years |
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