| 货号 | 20211-1mg |
| 描述 | L-Quisqualic acid is a natural analog of glutamate that acts as an agonist at AMPA-selective and metabotropic glutamate receptors (EC50s = 170, 10, 40, and 29 nM at GluR-A, mGluR1, mGluR3, and mGluR5, respectively), as well as the ionotropic kainate receptor (GRIK4; Ki = 6.43 nM).1,2,3,4,5,6 L-Quisqualic acid is used to study receptor dynamics and as an excitotoxin to selectively destroy neurons in the brain or spinal cord.7,8 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Schoepp, D.D.,Jane, D.E. and Monn, J.A. Pharmacological agents acting at subtypes of metabotropic glutamate receptors. Neuropharmacology 38(10), 1431-1476 (1999). 2.Bräuner-Osborne, H.,Egebjerg, J.,Nielsen, E.O., et al. Ligands for glutamate receptors: Design and therapeutic prospects. J. Med. Chem. 43(14), 2609-2645 (2000). 3.Bertrand, H.-O.,Besis, A.-S.,Pin, J.-P., et al. Common and selective molecular determinants involved in metabotopic glutamate receptor agonist activity. J. Med. Chem. 45(15), 3171-3183 (2002). 4.Kamboj, R.K.,Schoepp, D.D.,Nutt, S., et al. Molecular cloning, expression, and pharmacological characterization of humEAA1, a human kainate receptor subunit. J.Neurochem. 62(1), 1-9 (1994). 5.Mutel, V.,Ellis, G.J.,Adam, G., et al. Characterization of [3H]quisqualate binding to recombinant rat metabotropic glutamate 1a and 5a receptors and to rat and human brain sections. Journal of Neurochemistry 75(6), 2590-2601 (2000). 6.Uchino, S.,Sakimura, K.,Nagahari, K., et al. Mutations in a putative agonist binding region of the AMPA-selective glutamate receptor channel. FEBS Lett. 308(3), 253-257 (1992). 7.Lee, J.-W.,Furmanski, O.,Castellanos, D.A., et al. Prolonged nociceptive responses to hind paw formalin injection in rats with a spinal cord injury. Neurosci. Lett. 439(2), 212-215 (2008). 8.Muir, J.L.,Page, K.J.,Sirinathsinghji, D.J.S., et al. Excitotoxic lesions of basal forebrain cholinergic neurons: effects on learning, memory and attention. Behav. Brain Res. 57(2), 123-131 (1993). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | 4 |
| 纯度 | ≥99% |
| 计算分子量 | 189.1 |
| 分子式 | C5H7N3O5 |
| CAS号 | 52809-07-1 |
| 稳定性 | ≥ 1 year |
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