MMP-2 Inhibitor II
货号：
17267-1mg 基本售价：
616.0 元 规格：
1 mg
产品信息
概述| 货号 | 17267-1mg |
| 描述 | MMP-2 Inhibitor II is an oxirane p-sulfonamido analog of SB-3CT (Item No. 16337) that irreversibly inhibits matrix metalloproteinase-2 (MMP-2; Ki = 2.4 µM).1 It less potently inhibits MMP-1 and -7 (Kis = 45 and 379 µM, respectively) and does not inhibit MMP-3, -7, or -9.1 MMP-2 Inhibitor II, at 5 µM, attenuates glucose-induced MMP-2 activity and expression, as well as subsequent apoptosis, in retinal endothelial cells.2 It has also been used to examine the role of MMP-2 in rheumatoid synovial fibroblast survival, inflammation, and cartilage degradation.3 |
| 别名 | Matrix Metalloproteinase-2 Inhibitor II; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ikejiri, M.,Bernardo, M.M.,Bonfil, R.D., et al. Potent mechanism-based inhibitors for matrix metalloproteinases. The Journal of Biological Chemisty 280(40), 33992-34002 (2005).
2.Kowluru, R.A. and Kanwar, M. Oxidative stress and the development of diabetic retinopathy: contributory role of matrix metalloproteinase-2. Free Radical Biology & Medicine 46(12), 1677-1685 (2009).
3.Xue, M.,McKelvey, K.,Shen, K., et al. Endogenous MMP-9 and not MMP-2 promotes rheumatoid synovial fibroblast survival, inflammation and cartilage degradation. Rheumatology (Oxford) 53(12), 2270-2279 (2014).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 383.4 |
| 分子式 | C16H17NO6S2 |
| CAS号 | 869577-51-5 |
| 稳定性 | ≥ 2 years |
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