| 货号 | 17265-1mg |
| 描述 | BH3-interacting domain (Bid) is cleaved by caspase-8 to produce the truncated protein tBid, which facilitates cytochrome c release from mitochondria and drives apoptosis.1,2 BI-6C9 is an inhibitor of tBid (Kd = 20 µM), blocking the release of both cytochrome c and second mitochondria-derived activator of caspase from mitochondria.3,4 It prevents apoptosis in neurons treated with glutamate or oxygen-glucose deprivation.5,6 BI-6C9 (10 µM) also inhibits the nuclear translocation of apoptosis-inducing factor AIF, preventing the death of ovarian OVCAR-3 cancer cells induced by IFN-α2a.7 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Dejean, L.M.,Ryu, S.Y.,Martinez-Caballero, S., et al. MAC and Bcl-2 family proteins conspire in a deadly plot. Biochimica et Biophysica Acta 1797(6-7), 1231-1238 (2010). 2.Wei, M.C.,Lindsten, T.,Mootha, V.K., et al. tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c. Genes & Development 14(16), 2060-2071 (2000). 3.Becattini, B.,Sareth, S.,Zhai, D., et al. Targeting apoptosis via chemical design: Inhibition of bid-induced cell death by small organic molecules. Chemistry & Biology 11, 1107-1117 (2004). 4.Becattini, B.,Culmsee, C.,Leone, M., et al. Structure-activity relationships by interligand NOE-based design and synthesis of antiapoptotic compounds targeting Bid. Proceedings of the National Academy of Sciences of the United States of America 103(3), 12602-12606 (2006). 5.Landshamer, S.,Hoehn, M.,Barth, N., et al. Bid-induced release of AIF from mitochondria causes immediate neuronal cell death. Cell Death and Differentiation 15(10), 1553-1563 (2008). 6.Culmsee, C.,Zhu, C.,Landshamer, S., et al. Apoptosis-inducing factor triggered by poly(ADP-ribose) polymerase and Bid mediates neuronal cell death after oxygen-glucose deprivation and focal cerebral ischemia. Journal of Neuroscience 25(44), 10262-10272 (2005). 7.Miyake, K.,Bekisz, J.,Zhao, T., et al. Apoptosis-inducing factor (AIF) is targeted in IFN-α2a-induced Bid-mediated apoptosis through Bak activation in ovarian cancer cells. Biochimica et Biophysica Acta 1823(8), 1378-1388 (2012). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 471.6 |
| 分子式 | C23H25N3O4S2 |
| CAS号 | 791835-21-7 |
| 稳定性 | ≥ 2 years |
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