BI-D1870
货号：
15264-1mg 基本售价：
616.0 元 规格：
1 mg
产品信息
概述| 货号 | 15264-1mg |
| 描述 | The 90 kDa ribosomal S6 kinases (RSKs) are a group of serine/threonine kinases involved in diverse cellular processes, including growth, survival, and motility.1 BI-D1870 is a cell permeable, ATP-competitive inhibitor of the four vertebrate isoforms of RSK, RSK1-4 (IC50s = 31, 24, 18, and 15 nM, respectively).2 At 100 nM, it also significantly inhibits polo-like kinase 1, Aurora B, maternal embryonic leucine zipper kinase, and mammalian STE20-like kinase 2.2,3 BI-D1870 acts at the N-terminal kinase domain, but not the C-terminal domain, of RSK.2,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Romeo, Y.,Zhang, X. and Roux, P.P. Regulation and function of the RSK family of protein kinases. Biochemistry Journal 441(2), 553-569 (2012).
2.Sapkota, G.P.,Cummings, L.,Newell, F.S., et al. BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo. Biochemistry Journal 401(1), 29-38 (2007).
3.Bain, J.,Plater, L.,Elliot, M., et al. The selectivity of protein kinase inhibitors: A further update. Biochemistry Journal 408, 297-315 (2007).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 391.4 |
| 分子式 | C19H23F2N5O2 |
| CAS号 | 501437-28-1 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
