| 货号 | 15253-25ug |
| 描述 | Docosahexaenoic acid (DHA; Item No. 90310) is a nutritionally-derived ω-3 fatty acid that is abundant in the brain and the retina and is thought to be important in early development and for therapeutic approaches to inflammatory disorders and cancer.1,2,3,4,5 14(S)-HDHA is an oxygenation product of DHA that serves as a precursor to maresin 1 (Item No. 10878), an anti-inflammatory, pro-resolving mediator that prevents polymorphonuclear neutrophil (PMN) infiltration and stimulates macrophage phagocytosis.6 At doses as low as 0.2 ng/mouse 14(S)-HDHA administration resulted in reduced infiltration of PMNs into sites of inflammation.6 |
| 别名 | 14(S)-hydroxy Docosahexaenoic Acid;14(S)-HDoHE; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Su, H.M. Mechanisms of n-3 fatty acid-mediated development and maintenance of learning memory performance. Journal of Nutritional Biochemistry 21, 364-373 (2010). 2.Wu, T.C. and Chen, P.H. Health consequences of nutrition in childhood and early infancy. Pediatrics and Neonatology 50(4), 135-142 (2009). 3.Hong, S.,Tjonahen, E.,Morgan, E.L., et al. Rainbow trout (Oncorhynchus mykiss) brain cells biosynthesize novel docosahexaenoic acid-derived resolvins and protectins-Mediator lipidomic analysis. Prostaglandins & Other Lipid Mediators 78, 107-116 (2005). 4.De Caterina, R. n-3 Fatty acids in cardiovascular disease. New Engl.J.Med. 364(25), 2439-2450 (2011). 5.Serhan, C.N. Novel lipid mediators and resolution mechanisms in acute inflammation: To resolve or not? American Journal of Pathology 177(4), 1576-1591 (2011). 6.Serhan, C.N.,Yang, R.,Martinod, K., et al. Maresins: Novel macrophage mediators with potent antiinflammatory and proresolving actions. Journal of Experimental Medicine 206, 15-23 (2009). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 344.5 |
| 分子式 | C22H32O3 |
| CAS号 | 119433-37-3 |
| 稳定性 | ≥ 1 year |
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