| 货号 | 15216-5mg |
| 描述 | Conduritol B epoxide (CBE) is an irreversible inhibitor of glucocerebrosidase, also known as acid β-glucosidase, glucosylceramidase, GBA, or GBA1 (IC50 = 9 μM).1,2 Inhibition of this lysosomal glucosidase results in the accumulation of glucocerebroside without affecting cell viability, lysosomal enzyme release, or the activity of intracellular enzymes.3 It also does not inhibit non-lysosomal glucosylceramidase or cytosolic β-glucosidase.4 As glucocerebrosidase deficiency results in Gaucher disease, a common lysosomal storage disorder that can involve defects in blood, bone, neurological, and liver development, CBE is used in in vitro and animal models of the disease.2,4 |
| 别名 | CBE; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Ogawa, S.,Uetsuki, S.,Tezuka, Y., et al. Synthesis and evaluation of glucocerebrosidase inhibitory activity of anhydro deoxyinositols from (+)-epi- and (−)-vibo-quercitols. Bioorganic & Medicinal Chemistry Letters 9(11), 1493-1498 (1999). 2.Witte, M.D.,Kallemeijn, W.W.,Aten, J., et al. Ultrasensitive in situ visualization of active glucocerebrosidase molecules. Nature Chemical Biology 6(12), 907-913 (2010). 3.Newburg, D.S.,Yatziv, S.,McCluer, R.H., et al. β-Glucosidase inhibition in murine peritoneal macrophages by conduritol-B-epoxide: An in vitro model of the Gaucher cell. Biochim.Biophys.Acta. 877(1), 121-126 (1996). 4.Ishibashi, Y.,Kohyama-Koganeya, A. and Hirabayashi, Y. New insights on glucosylated lipids: metabolism and functions. Biochim Biophys.Acta. 1831(9), 1475-1485 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 162.1 |
| 分子式 | C6H10O5 |
| CAS号 | 6090-95-5 |
| 稳定性 | ≥ 2 years |
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